MSc thesis project proposal
Biodegradable microfabricated Organ-on-chip platform for PERFUSED ORGANOIDS
OoC systems are microfluidic cell culture devices that recapitulate in vivo-like microenvi-ronments to support the expression of properties and functions of human tissues and organs. Such microphysiological systems represent more realistic models than existing in vitro cell cultures, which should enhance pre-clinical screening of the effect of drugs and other compounds on the human body. This project focuses on the development of a biodegradable microfabricated platform for perfused organoids.
It will be performed in close collaboration with biologists from the Netherlands Organ-on-Chip Initiative (NOCI).
Assignment
The student will perform the assignment at ECTM:
- Duration: 9-12 months
- Location: ECTM and EKL facilities at TU Delft
The expected activities
- Synthesis and characterization of biodegradable material to be used in the OoC platform
- Design and fabrication of the biodegradable microfabricated platform for perfused organoids
- In vitro study with brain organoids and blood vessel cells in a proof a concept study
Requirements
You are an ambitious student looking for a challenging thesis project on microfabrication of Organs-on-Chip for medical applications. You have a biomedical engineering, material science, mechanical or microelectronics background. Good communication skills in English and a pro-active attitude are expected.
Contact
dr. Clementine Boutry
Electronic Components, Technology and Materials Group
Department of Microelectronics
Last modified: 2022-12-16